1. What is DFI?
DFI stands for Sperm DNA Fragmentation Index. It measures the percentage of sperms in a sample with DNA breaks/fragments which is a marker of DNA damage.
2. For whom is it done?
DFI is suggested for couples with
Unexplained infertility
Recurrent pregnancy loss
IUI failures
IVF or ICSI failures
3. What is normal DFI?
15% or less fragmentation : excellent sperm DNA integrity
15 to 30% : good to fair
More than 30%: poor sperm DNA integrity
4. What are the causes for high DFI?
Infections
Cigarette smoking
Drug abuse
Exposure to environmental and occupational pollutants
Advanced age / varicocele
Illness with high fever
Elevated testicular temperature (laptops, hot tubs)
Chronic diseases like diabetes, cancer and cancer treatment, poor diet and obesity
5. How does this test help in treatment?
High DFI can cause fertility issues. Measures to reduce oxidative stress help decrease DFI and improve fertility potential
6. Measures to follow to reduce DFI?
Avoid hot tubs and tight fitting underwears
Healthy diet full of fruits and vegatables, rich in antioxidants.
Exercise regularly
Avoid smoking and alcohol consumption
Evaluate varicoceles with a urologist and take an opinion regarding surgical correction
Use supplements containing vitamins and antioxidants